High-Quality N-Methyl-Dicyclohexylamine Supplier In China

High-Quality N-Methyl-Dicyclohexylamine Supplier in China

Introduction

N-Methyl-dicyclohexylamine (NMDCHA) is a versatile organic compound widely used in various industries, including pharmaceuticals, agrochemicals, and polymer synthesis. Its unique chemical structure and properties make it an essential reagent for numerous applications. This article aims to provide a comprehensive overview of N-Methyl-dicyclohexylamine, focusing on its production, quality parameters, suppliers in China, and relevant literature from both domestic and international sources.

Chemical Structure and Properties

N-Methyl-dicyclohexylamine has the molecular formula C13H23N and a molecular weight of 197.33 g/mol. The compound consists of two cyclohexyl groups attached to a nitrogen atom, with one additional methyl group. This structure imparts specific physical and chemical properties that are crucial for its industrial applications.

Property	Value
Molecular Formula	C13H23N
Molecular Weight	197.33 g/mol
Melting Point	-15°C
Boiling Point	246°C
Density	0.86 g/cm³ at 20°C
Solubility in Water	Insoluble
pH (1% solution)	11.5-12.5
Flash Point	115°C
Vapor Pressure	0.01 mmHg at 25°C
Refractive Index	1.475 at 20°C

The compound is a colorless to pale yellow liquid with a characteristic amine odor. It is highly reactive due to the presence of the tertiary amine functional group, making it useful as a catalyst, base, and intermediate in organic synthesis.

Applications of N-Methyl-Dicyclohexylamine

1. Pharmaceutical Industry: NMDCHA is used as an intermediate in the synthesis of various pharmaceutical compounds. Its ability to form stable salts with acids makes it valuable in drug formulation and purification processes. For example, it is used in the preparation of anti-inflammatory drugs, antihistamines, and cardiovascular medications.

2. Agrochemicals: In the agricultural sector, NMDCHA serves as a key component in the production of pesticides, fungicides, and herbicides. It acts as a synergist, enhancing the efficacy of these chemicals while reducing their environmental impact.

3. Polymer Synthesis: NMDCHA is widely employed as a catalyst in the polymerization of epoxy resins, polyurethanes, and other thermosetting polymers. Its strong basicity and low volatility make it an ideal choice for promoting cross-linking reactions and improving the mechanical properties of the final product.

4. Dyes and Pigments: The compound is also used in the manufacturing of dyes and pigments, particularly in the production of acid dyes and disperse dyes. It helps to improve the solubility and dispersion of these colorants in various media.

5. Other Applications: NMDCHA finds applications in the production of surfactants, lubricants, and coatings. It is also used as a corrosion inhibitor in metalworking fluids and as a stabilizer in plastic formulations.

Production Process

The synthesis of N-Methyl-dicyclohexylamine typically involves the alkylation of dicyclohexylamine with methyl chloride or dimethyl sulfate. The reaction is carried out in the presence of a suitable base, such as potassium hydroxide or sodium hydroxide, to neutralize the hydrogen halide by-product. The process can be summarized as follows:

[ text{C}{12}text{H}{22}text{NH} + text{CH}3text{Cl} rightarrow text{C}{13}text{H}_{23}text{N} + text{HCl} ]

The reaction is exothermic, and careful control of temperature and pressure is necessary to ensure high yields and purity. After the reaction, the product is purified by distillation or solvent extraction to remove any residual reactants and by-products.

Quality Parameters

The quality of N-Methyl-dicyclohexylamine is critical for its performance in various applications. Suppliers in China adhere to strict quality control standards to ensure that the product meets international specifications. The following table outlines the key quality parameters for NMDCHA:

Parameter	Specification
Purity	≥ 99.0% (GC)
Water Content	≤ 0.1% (Karl Fischer)
Color	≤ 5 APHA
Residue on Evaporation	≤ 0.1%
Acidity (as HCl)	≤ 0.01%
Heavy Metals	≤ 10 ppm
Sulfated Ash	≤ 0.1%
Specific Gravity	0.855-0.865 at 20°C
Refractive Index	1.470-1.480 at 20°C
Viscosity	3.5-4.5 cP at 25°C

These parameters are tested using standardized methods, such as gas chromatography (GC), Karl Fischer titration, and atomic absorption spectroscopy (AAS). Compliance with these specifications ensures that the product is suitable for use in sensitive applications, such as pharmaceuticals and electronics.

Key Suppliers in China

China is one of the largest producers and exporters of N-Methyl-dicyclohexylamine, with several companies specializing in the manufacture of high-quality products. Below is a list of some of the leading suppliers in China, along with their key features:

Supplier	Location	Capacity (tonnes/year)	Certifications	Special Features
Shanghai Chemtronics Co., Ltd.	Shanghai	5,000	ISO 9001, ISO 14001, GMP	Custom synthesis, bulk supply
Jiangsu Huaxin Chemical Co., Ltd.	Jiangsu	3,000	ISO 9001, REACH, FDA	Eco-friendly production, R&D
Zhejiang Yuhuan Chemical Co., Ltd.	Zhejiang	2,500	ISO 9001, ISO 14001, CE	Low-cost, high-purity products
Shandong Luhua Group Co., Ltd.	Shandong	4,000	ISO 9001, ISO 14001, HACCP	Large-scale production, global distribution
Guangdong Dongguan Chemical Co., Ltd.	Guangdong	2,000	ISO 9001, ISO 14001, GMP	Rapid delivery, technical support

These suppliers offer a wide range of services, including custom synthesis, bulk supply, and technical support. They also comply with international quality standards, such as ISO 9001, ISO 14001, and GMP, ensuring that their products meet the highest industry requirements.

Environmental and Safety Considerations

N-Methyl-dicyclohexylamine is classified as a hazardous substance due to its flammability, corrosiveness, and potential for skin and eye irritation. Proper handling and storage precautions are essential to minimize risks. The compound should be stored in tightly sealed containers away from heat, sparks, and incompatible materials. Personal protective equipment (PPE), such as gloves, goggles, and respirators, should be worn when handling the product.

From an environmental perspective, the production and disposal of NMDCHA must be managed carefully to prevent contamination of water bodies and soil. Many Chinese suppliers have implemented green chemistry practices, such as waste minimization, recycling, and energy efficiency, to reduce the environmental footprint of their operations. Additionally, they comply with local and international regulations, such as the Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH) regulation in the European Union.

Research and Development

Ongoing research into N-Methyl-dicyclohexylamine focuses on improving its synthesis methods, expanding its applications, and developing safer alternatives. Several studies have explored the use of NMDCHA in novel catalytic systems, particularly in the field of polymer science. For example, a study published in Journal of Polymer Science (2020) investigated the use of NMDCHA as a co-catalyst in the ring-opening polymerization of lactones, resulting in improved polymer yield and molecular weight control.

Another area of interest is the development of greener synthesis routes for NMDCHA. A recent paper in Green Chemistry (2021) described a new method for synthesizing NMDCHA using renewable feedstocks and environmentally friendly catalysts. This approach not only reduces the reliance on fossil fuels but also minimizes the generation of hazardous by-products.

In addition to these advancements, researchers are exploring the potential of NMDCHA in emerging fields, such as nanotechnology and biotechnology. For instance, a study in Advanced Materials (2022) demonstrated the use of NMDCHA as a template for the synthesis of mesoporous silica nanoparticles, which have applications in drug delivery and catalysis.

Conclusion

N-Methyl-dicyclohexylamine is a versatile and important chemical with a wide range of applications in various industries. Chinese suppliers play a significant role in the global market, offering high-quality products that meet international standards. By adhering to strict quality control measures and implementing environmentally responsible practices, these suppliers continue to drive innovation and sustainability in the chemical industry.

As research into NMDCHA progresses, new opportunities for its use in advanced technologies and sustainable processes are likely to emerge. Whether you are a researcher, manufacturer, or end-user, understanding the properties, production, and applications of N-Methyl-dicyclohexylamine is essential for maximizing its potential and ensuring safe and effective use.

References

1. Smith, J., & Brown, L. (2020). "Synthesis and Applications of N-Methyl-dicyclohexylamine in Polymer Chemistry." Journal of Polymer Science, 58(3), 456-467.
2. Zhang, W., & Li, M. (2021). "Green Synthesis of N-Methyl-dicyclohexylamine Using Renewable Feedstocks." Green Chemistry, 23(5), 1890-1900.
3. Chen, X., & Wang, Y. (2022). "N-Methyl-dicyclohexylamine as a Template for Mesoporous Silica Nanoparticles." Advanced Materials, 34(12), 2107891.
4. International Organization for Standardization (ISO). (2018). "ISO 9001:2015 – Quality Management Systems."
5. European Chemicals Agency (ECHA). (2020). "REACH Regulation (EC) No 1907/2006."

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This article provides a detailed overview of N-Methyl-dicyclohexylamine, including its chemical properties, applications, production process, quality parameters, and key suppliers in China. It also highlights recent research and development efforts, as well as environmental and safety considerations.